SPEAKER
Prof Mónica CAMPILLOS
Director, Ludwig Boltzmann Institute
Group leader at Helmholtz Zentrum
München (HMGU),
German Research Center for Environmental
Health, Munich, Germany
(Systems Pharmacology)
HOST:
Department of Oncology
RESPONSIBLE LIH SCIENTIST:
Dr Francisco AZUAJE
(francisco.azuaje@lih.lu)
www.lih.lu
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BIOLOGICAL INTERROGATION OF INTEGRATED RESOURCES OF
HIGH-THROUGHPUT CHEMICAL AND PHENOTYPIC DATA OF PERTURBATIONS
ABSTRACT
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In this talk, I will give an overview of the
research activities of my research group
at the Helmholtz Zentrum München.
We are interested in understanding the
phenotypic response of chemical and
genetic perturbations in mammalian organism.
To that aim, we have developed
integrated resources and tools of
high-throughput chemical screens as
well as organismal phenotypes from genetic
and chemical perturbations. These
include the target prediction method HitPick
and the Organ System Heterogeneity database.
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The interrogation of these resources using
systems biology approaches has revealed
novel insights into the drug/target/
phenotype relation, extending the
current knowledge on drug action. For
example, we have predicted novel drug
contraindications exploiting the similarity
of drug side effects and disease
symptoms. The application of novel drug
target de-convolution methods to chemical
high-throughput screens have enabled to
uncover new connections between
drugs targets and phenotypes. Novel
findings have been experimentally validated
in collaboration with lab research
groups.
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