SPEAKER
Prof. François FUKS
Laboratory of Cancer Epigenetics
& ULB-Cancer Research Center (U-CRC),
Brussels, Belgium
HOST:
Department of Oncology
RESPONSIBLE LIH SCIENTISTS:
Simone Niclou
(simone.niclou@lih.lu)
Sabrina Fritah
(sabrina.fritah@lih.lu)
www.lih.lu
www.uni.lu
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EPIGENETICS AND EPIGENOMICS IN HEALTH AND DISEASES
ABSTRACT
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Since chemical modifications of DNA or
histones are reversible processes, there
is potentially a huge benefit in modulating
such modifications for the treatment of
human cancers using pharmacological
drugs. To achieve such anti-cancer therapy,
it is essential to decipher the molecular
mechanisms underlying epigenetic and
epigenomic perturbations in tumours.
We will present our recent efforts, using
our epigenomic plateform EPICS
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(www.epics.ulb.be), to better understand
and map epigenetic alterations in cancers,
including DNA methylation and
hydroxymethylation.
We will also discuss about our very recent
work on an emerging realm of biological
regulation, termed RNA epigenetics. We
will present our ongoing attempts to decipher
the roles of a novel RNA modification: RNA
hydroxymethylation.
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