SPEAKER
Prof Jochen PREHN
Professor of Physiology & Director, Centre
for Systems Medicine, Royal College of
Surgeons in Ireland
HOST:
LIH / University of Luxembourg
RESPONSIBLE LIH SCIENTISTS:
Reinhard Schneider
(reinhard.schneider@uni.lu)
www.lih.lu
www.uni.lu
|
TRANSLATING SYSTEMS BIOLOGY-BASED SIGNATURES AS
PROGNOSTIC CANCER BIOMARKERS AND STRATIFICATION
TOOLS
ABSTRACT
|
Professor Prehn is considered an international
authority on the single-cell analysis and the
molecular control of apoptosis, cancer cell
death, nerve cell death, as well as mitochondrial
function and dysfunction. This
research included the development of
computational approaches to understand
bio- energetics, apoptosis sensitivity and
apoptosis resistance at a systems level. In
collaboration with clinicians (pathology,
medicine, and surgery), Prof Prehn translated
these approaches into clinically relevant
settings, and has initiated multiple large scale,
multi-partner clinical projects such as the
APO-COLON and APO-DECIDE clinical studies.
|
In his presentation, Prof Prehn will highlight
his recent research applying quantitative
and systems-based analyses of BCL-2
signalling, caspase signalling and cellular
bioenergetics pathways. These processes
represent key downstream targets of oncogenic
transformation. He will in particular
showcase the application of dynamic systems
modelling for the identification of
novel prognostic biomarkers and stratification
tools for the treatment of colorectal
cancer (CRC) and other solid tumours.
|
|